Pages

OH conjugate addition

This needs an acid or base catalyst.

Base

Alcohols are not very good nucleophiles, but alkoxide anions are great ones. So we can use a base to deprotonate some of the alcohols.


It can also happen intramolecularly:


Intramolecular reactions are usually much faster than intermolecular ones, this is why the above reaction can use MeO- as a base without having it compete by acting as a nucleophile.

Acid

Alcohols are not very good nucleophiles, but a C=OH+ is very easy to attack. So we can make the reaction go by protonating the C=O:

No comments:

Post a Comment